웅비메디텍은 여러분의 연구를 응원합니다
In embryonic development, Bone morphogenetic proteins (BMPs) promote endothelial specification and subsequent vascular differentiation. A subset of tissue-resident endothelial cells, referred to as endothelial stem/progenitor cells, have regenerative capacity in response to injury and are believed to retain phenotypic flexibility. Transplantation of such cells can represent a novel cell-based therapy for vasculopathies.
 
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BMP Signaling in Vascular Diseases
 
BMP-2 and BMP-4 appear to be both markers and drivers of vascular calcification, an important indictor of increased risk for atherosclerosis. For a broader representation of atherosclerosis disease progression, view our poster.
 
 
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Publication Spotlight: Microtissues for Modelling Multicellular Cardiac Diseases
 
In this paper, a mixture of cytokines including BMP-4, were used to supplement the differentiation of hiPSC’s into cardiac stromal cells shown to enhance maturation in 3D cardiac microtissues.