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Fluorescent-Labeled Recombinant Proteins for CAR-T Cells
CAR-T cell therapy is based on the principle that T cells removed from a patient or donor can be genetically engineered to express a specific chimeric antigen receptor (CAR). Once these CAR-T cells are infused back into the patient, the CAR will bind to its specific target antigen on the surface of the patient's tumor cells, activating the T cells, and allowing them to attack and destroy the tumor cells.
Flurescent-Labeled Protein?
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Detection of CD19-CAR-T Cells with Recombinant Human CD19 Fc Chimera Atto 647N Protein. CD4+CD8+ T cells were either (A) transduced with a hCD19-CAR or (B) not transduced, and then cultured for 11 days. Cells were stained with a PE-Cy7-CD4 and Recombinant Human CD19 Fc Chimera Atto 647N Protein (Catalog # ATM9269), and detected by flow cytometry.
Fluorescent-labeled Proteins to Detect CAR-T Cells
| Protein | Species | Source | Tag | Fluorescent Label | Catalog # |
| BCMA | Human | NS0 | Fc | Alexa 488 | AFG193 |
| Alexa 647 | AFR193 | ||||
| Atto 488 | ATJ193 | ||||
| Atto 647N | ATM193 | ||||
| CD19 | Human | CHO | Fc | Alexa 488 | AFG9269 |
| Alexa 647 | AFR9269 | ||||
| Atto 488 | ATJ9269 | ||||
| Atto 647N | ATM9269 | ||||
| Mesothelin | Human | NS0 | His | Alexa 488 | AFG3265 |
| Alexa 647 | AFR3265 | ||||
| MUC-1 | Human | HEK293 | Fc | Alexa 488 | Coming soon |
| Alexa 647 | AFR10332 | ||||
| OX40 | Human | NS0 | Fc | Alexa 488 | AFG3388 |
| Alexa 647 | AFR3388 | ||||
| Siglec-2 / CD22 | Human | NS0 | Fc | Atto 488 | ATJ1968 |
| Atto 647N | ATM1968 | ||||
| Siglec-3 / CD33 | Human | NS0 | Fc | Alexa 488 | AFG1137 |
| Alexa 647 | AFR1137 | ||||
| Atto 488 | ATJ1137 | ||||
| Atto 647N | ATM1137 | ||||
| TSLPR | Human | NS0 | Fc | Alexa 488 | AFG981 |
| Alexa 647 | Coming soon |
Alexa Fluor SARS-CoV-2 Spike Proteins
| Variant | Description | Source | Label | Catalog # |
| SARS-CoV-2 | Val16-Lys1211 | HEK293 | Alexa 488 | AFG10561 |
| Alexa 647 | AFR10561 | |||
| SARS-CoV-2 | Spike RBD Arg319-Phe541 |
HEK293 | Alexa 488 | AFG10500 |
| Alexa 647 | AFR10500 | |||
| Alpha | B.1.1.7 Val16-Lys1211 H69del, V70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H |
HEK293 | Alexa 488 | AFG10796 |
| Alexa 647 | AFR10796 | |||
| Beta | B.1.351 Val16-Lys1211 D80A, D215G, L242del, A243del, L244del, K417N, E484K, N501Y, D614G, A701V |
HEK293 | Alexa 488 | AFG10786 |
| Alexa 647 | AFR10786 | |||
| Gamma | P.1 Val16-Lys1211 L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I |
HEK293 | Alexa 488 | AFG10795 |
| Alexa 647 | AFR10795 | |||
| Delta | B.1.617.2 Val16-Lys1211 T19R, G142D, F157del, R158del, L452R, T478K, D614G, P681R, D950N |
HEK293 | Alexa 488 | AFG10878 |
| Alexa 647 | AFR10878 | |||
| Kappa | B.1.617.1 Val16-Lys1211 G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H |
HEK293 | Alexa 488 | AFG10861 |
| Alexa 647 | AFR10861 |
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